Yoshiaki Omura, M.D., Sc.D., FACA, FICAE, FAAIM, FRSM
Director of Medical Research, Heart Disease Research Foundation; President, Intl College ofAcupuncture & Electro-Therapeutics; President, Japan Bi-Digital O-Ring Test Medical Society;Adjunct Prof., Dept. of Community & Preventive Medicine, New York Medical College;Prof., Dept. of Non-Orthodox Medicine, Ukrainian National Kiev Medical Univ.
(Correspondence: 800 Riverside Dr (8-1), NYC, 10032, Tel: (212) 781-6262; Fax:(212) 923-2279)

ABSTRACT
Even when one can prevent or survive major causes of death, cardio-vascular diseases andcancer, once individual manages to reach 80 years old, more than 20% of the people over 80 develop Alzheimer’s Disease. Although there are some medications which can slow down the progress of Alzheimer’s disease there is no reliable method of reversing Alzheimer’s disease. Since old age population is increasing every year in developed countries expenses and burden of taking care of Alzheimer’s disease will become astronomical. Similarly population of Autism patients among children is also increasing every year and there is no reliable treatment for Autism available. As a result these people become an additional burden for the families and society. During the past 5 years the author has been evaluating both Alzheimer’s patient and Autism patient and found that they have a significantly similar abnormal findings in the brain. The author often found the following common findings among Alzheimer’s and Autism patients:
1) Excessive deposit of metal such as Aluminum (Al) and mercury (Hg) with or without lead (Pb) in Hippocampus &, rest of brain, particularly motor cortex
2) Acetylcholine (neurotransmitter) is markedly reduced in Hippocampus& rest of brain, particularly motor cortex
3) ß- Amyloid (1-42) (protein fragment forming plaques if not broken down normally) is markedly increased in Hippocampus & rest of brain, particularly motor cortex
4) Strong Viral infection exist often due to cytomegalovirus (CMV) and HHV-6 in Hippocampus & rest of brain, particularly motor cortex.
5) Bacterial Infection exist often due to Chlamydia Trachomatis and Mycobacterium Tuberculosis in Hippocampus & rest of brain, particularly motor cortex.

To remove excessive metals, Cilantro, originally discovered for its chelating effects on metals such as Al, Hg, Pb, etc.(made by Hayashibara Biochemical Lab of Okayama, Japan) is used. As safe, natural, effective antiviral agent, mixture of EPA 180mg and 120mg DHA 4 times/day was used for adults; however for autistic children optimal dose is measured individually using Bi-Digital O-Ring Test. Selective Drug Uptake Method to the brain is performed either by
stimulation of the brain representation area at the 1st segment of the middle finger, either mechanically or by red spectral light from LED. More than 95% of the excess metal deposit in hippocampus and rest of brain can be removed with Cilantro and Selective Drug Uptake Enhancement to selectively deliver the Cilantro to the brain within several hours. Once major part of excessive deposit of metal is removed from brain, Acetylcholine often increases 2 or 3X of the original abnormally reduced amount without any other treatment. Within the past 2 years,
the author discovered that the 2 major causes of the increase in water insoluble ß-Amyloid (1-42) is due to brain infection (particularly hippocampus) of Chlamydia Trachomatis and Mycobacterium Tuberculosis. The author also succeeded in reducing in a majority of the patients ß-Amyloid (1-42) to normal level and in more than 70% of the patients not only stop the progress of Alzheimer’s disease and Autism patient but also often able to successfully revert to normal condition by treating Chlamydia Trachomatis and Mycobacterium Tuberculosis successfully if the patient was diagnosed within 2 or 3 years.
Two years ago the author found that the most common major cause of increase in ß-Amyloid (1-42) in brain is Chlamydia Trachomatis infection of the brain. In 2002, the author found in a woman patient, he was able to reduce the amount of ß-Amyloid (1-42) from 12ng to 6ng by treating her Chlamydia Trachomatis infection of more than 1500ng , but he could not reduce it any further. Upon further evaluation of the brain the author found extensive Mycobacterium
Tuberculosis infection of 40 µg and short term memory deficiency could not completely be eliminated in this 30 year old young woman. In addition she had CMV infection and HHV-6 both of which were sensitive to mixture of 180mg of EPA and 120mg of DHA, and she had a bacterial infection sensitive to Trimox (Amoxicillin made by Bristol Meyers). When multiple mixed infections co-exist, ideally, all the infections should be treated at the same time as it is often observed when only one infection is treated, other bacterial or viral infections are often increased; however, in the past it was often not possible due to the drug interactions, when multiple drugs are given at the same time. For example, for Chlamydia Trachomatis infection, Azithromycin is among the most effective antibiotics for Chlamydia Trachomatis, but it is not compatible with a mixture of EPA+ DHA as well as Trimox, and therefore due to canceling effect Azithromycin cannot be used with these medications to treat multiple infections.
However, Doxycycline which is also effective for Chlamydia Trachomatis is compatible with a mixture of EPA+ DHA as well as Trimox. On the other hand the most commonly used medication for the treatment of Mycobacterium Tuberculosis is Isoniazide often with additional Rifampin, but Isoniazide is not compatible with a mixture of EPA+ DHA which we use as a safe and effective anti-viral agent, and also not compatible with Trimox which is one of the broadest
spectrum anti-bacterial agent. In addition, in order to get a good result one has to continually use Isoniazide 2 times a day, at least 1 or 2 years; but it often produces liver toxicity, and many people can not continue treatment full term. Even a small amount of alcohol, such as a 1/2 cup of beer produces liver damage and the patient often feels completely exhausted. To solve this
problem the author evaluated about 150 different traditional Chinese and Japanese herb medicines made by Tsumura Pharmaceutical Company of Japan, and found one herb medicine called Saikokeishito (Tsumura Product No. 10) was found to have a more efficient anti-Mycobacterium Tuberculosis effect, and up to now has shown no significant side effects. Saikokeishito was found to be compatible with a mixture of EPA+ DHA and also compatiblewith Trimox, but it is not compatible with Doxycycline used to treat Chlamydia Trachomatis;
because of this limitation we could not simultaneously treat all the viruses and bacteria including Chlamydia Trachomatis, and Mycobacterium Tuberculosis at the same time. Indigo plant is known empirically to have beneficial effect on some of Diabetic patients. According to the author's clinical research most common cause of Diabetes is either CMV infection, Chlamydia Trachomatis infection, or mixed infection of the CMV and Chlamydia Trachomatis. Since the author found that Indigo Plant is beneficial for Diabetes only due to Chlamydia Trachomatis infection while it is not effective for Diabetes due to CMV alone.
Hayashibara Biochemical Laboratory extracted 9 major components of Indigo Plant for the author to evaluate. All of the originally 9 extracts were toxic, and had no beneficial effects. However, after the author diluted all of 9 extracts 2X, 3X, and 4X and then the author found only one of 9 to be beneficial for Chlamydia Trachomatis infection. This substance Indigo 9-1 which is an effective form of one of the 9 major components of Indigo plant which the author found to have an anti-Chlamydia Trachomatis effect. Originally, when components was isolated by Dr. Fukuda and his associates of Hayashbara Biochemical Laboratory of Okayama City, Japan, the author found that it has a definite anti-Chlamydia
Trachomatis effect, but unfortunately its effective duration was an average of one hour and therefore we could not treat the patient effectively, as no patient wants to take medicine 12 times a day. To solve this problem, when the author and Hayashibara Biochemical researchers slightly modified original natural preparation of effective component to prolong the duration, its effective duration was enhanced to an average of 6-8 hours; as a result the author found it had
not only most powerful anti-Chlamydia effect, but also with no known side effect, and we named this natural substance as "Substance Z". "Substance Z" has additional advantages, namely it is compatible with mixture of EPA+ DHA, it is compatible with Trimox, and it is compatible with Saikokeishito. Thus since 2002, it becomes possible to treat Mycobacterium tuberculosis and Chlamydia Trachomatis at the same time, along with other bacterial infections sensitive to
Trimox, and viral infection sensitive to the mixture of EPA+ DHA as an anti-viral agent. In treating a patient with all these multiple infections including viral infection sensitive to mixture of EPA + DHA, bacterial infection sensitive to Trimox, Chlamydia Trachomatis sensitive to "Substance Z" and Mycobacterium Tuberculosis sensitive to Saikokeishito (once optimal dose of each medication is determined for each individual patient) all at the same time without mutually canceling effect of drug interactions. In addition, use selective drug uptake
enhancement method by delivering drugs selectively to the pathological area of the brain, by stimulating organ representation area of the brain on the first segment of the middle fingers, or the brain representation area of the underside of the tongue or ear lobules by either mechanical stimulation or red spectral light stimulation. As a result we are now able to eliminate most of the infections significantly within a few days, and elimination of the above listed abnormal findings in the brain. In the normal brain, ß-Amyloid (1-42) is less than 3ng, but when it increases above 4 or 5 ng often people develop short term memory deficiency, and when its increases between 7 and 12ng it is considered to be early stage of Alzheimer’s disease. And Acetylcholine normally should
have at least 1500µg, but when it is reduced below 500µg brain dysfunction began to appear but it becomes noticeable by others when its reduced below 500µg; in early stage of Alzheimer’s disease it goes down between 200 and 100µg, and in most of the advanced Alzheimer’s patients Acetylcholine is below 150 – 100µg. With the latest effective safe treatment described above,
when we eliminate most of the infections to practically 0 such as Chlamydia Trachomatis and Mycobacterium Tuberculosis are <l zg (=10-21g), short term memory deficiency will disappear particularly when ß-Amyloid (1-42) become less than 2 or 3 ng. However, in the advanced old Alzheimer’s patient, when the ß-Amyloid is increased to 12 or 20ng for a period of more than 3 or 4
years, often neurons are already damaged irreversibly, as a result even when we succeed in lowering ß-Amyloid (1-42) to less than 2 or 3 ng short term memory cannot be reversed and therefore it is most important to make early diagnosis and treat them as quickly as possible. Similarly, in Autism patient the problem usually started at the time of birth, but most of the parents and physicians only recognize when children reaches 1 1/2 or 2 years old, and thus it is important to detect non-invasively above described abnormal biochemical changes and
infections. Ideally, they should be examined shortly after birth. In the case of Autism (unlike advanced Alzheimer’s patient) often it is possible to reverse partially and sometimes even significantly with more than 3 or 4 year history.